第十六屆共濟失調(diào)性毛細血管擴張癥研討會（Ataxia-Telangiectasia Workshop, ATW-2015）暨第六屆DNA損傷應(yīng)答與人類疾病國際研討會（international symposium on DNA Damage Response & Human Disease, isDDRHD-2015）將于2015年10月11-14日在首都師范大學(xué)召開，這是從1980年起不定期在世界各地舉辦的ATW與由首都師大DNA損傷應(yīng)答北京市重點實驗室于2010年創(chuàng)辦的isDDRHD年會系列聯(lián)合的國際會議。本次會議由首都師大DNA損傷應(yīng)答北京市重點實驗室、北京細胞生物學(xué)會、德國Fritz Lipmann研究所、中國細胞生物學(xué)會信號轉(zhuǎn)導(dǎo)分會共同主辦。

共濟失調(diào)性毛細血管擴張癥（A－T）的致病基因編碼調(diào)控DNA損傷應(yīng)答的核心激酶ATM，A-T病人的核心特征之一是對DNA損傷非常敏感。因此，ATW-2015/isDDRHD-2015的主題包括A-T疾病的生物學(xué)基礎(chǔ)與臨床、ATM/ATR介導(dǎo)的DNA損傷應(yīng)答、基因組不穩(wěn)定性與癌癥及神經(jīng)退行性病變等。本次大會將邀請50名國內(nèi)外知名專家做大會交流，包括大會keynote speakers Drs. Tanya Paul和Howard M. Lederman、EMBO keynote speaker Dr. Yosef Shiloh，并將從遞交的摘要中遴選10份作為大會口頭報告，為青年學(xué)者提供10個名額的旅行資助（每人500美元），設(shè)置6個poster awards（每個300美元，其中兩個是EMBO poster awards），這些機會將為本領(lǐng)域的年輕科學(xué)工作者提供向國際上一流科學(xué)家學(xué)習(xí)和展示自己工作的機會。

October 11th, Sunday, 2015

16:00-18:00?
Keynote speeches

16:00-17:00
Tanya Paull (USA): ATM activation and oxidative stress responses?

17:00-18:00
Howard M. Lederman (USA): Clinical Care of People with A-T: Two Decades of Progress

18:30
Welcome reception

October 12th, Monday, 2015

08:30-08:45
Opening ceremony

08:45-12:05
Neurodegeneration in A-T (I)

EMBO Keynote Speech

08:45-9:10
Yossi Shiloh (Israel): Ataxia-telangiectasia: attempting to understand the cerebellar phenotype

09:10-09:35
Peter McKinnon (USA): ATM Function in the Nervous System?

9:35-10:00
Keith Caldecott (UK): PARP1 and DNA single-strand break induced neurological disease?

10:00-10:30?
Group photo and tea break

10:30-10:55
Penny Jeggo (UK): Adult neuronal stem cells sensitively activate ATM dependent apoptosis?

10:55-11:20
Ari Barzilai (Israel): The role of Atm in brain functionality

11:20-12:05
Selected talks (3 × 15’)

12:05 Lunch

13:00-14:30
Neurodegeneration in A-T (II)

13:00-13:25
Zhao-Qi Wang (Germany): MRN in neurodelgeneration

13:25-13:50
Karl Herrup (HK): Back to the future: the role of ATM in late-onset neurodegenerative disease?

13:50-14:15
Martin Lavin (Australia): Rat model for ataxia telangiectasia

14:15-15:00
Selected talks (3 × 15’)

15:30-17:30
Poster session I (odd-numbered posters)

17:30-19:30
Poster session II (even-numbered posters)

19:30 Dinner hosted by CNU

October 13th, 2015

08:00-09:40
DNA damage response and cancer (I)

08:00-08:25
Fred Alt (USA): Role of the ATM DNA DSB Response Pathway in IgH CSR, Chromosomal Translocations and Lymphoma

08:25-08:50
Cong Liu (China): A CRL4 ubiquitin ligase facilitates chromatin recruitment of Exo1 to promote long-range resection of double strand breaks

08:50-09:15
Jun Huang (China): A novel helicase in DNA repair

09:15-09:40
Jan Karlseder (USA): Telomere function during senescence and crisis?

09:40-10:00
Tea break

10:00-12:30
Therapy for A-T

10:00-10:25
Luciana Chessa (Italy): New insight in the steroid therapy of Ataxia Telangiectasia?

10:25-10:50
Tom Crawford (USA): Advances in clinical neurology assessments of A-T at Johns Hopkins?

10:50-11:15
Domenico Delia (Italy): Activity-dependent responses and transcriptional regulation in iPSC-derived neurons from A-T patients?

11:15-12:40
Malcolm Taylor (UK): The increasing range of clinical and cellular variation in ataxia telangiectasia

12:40-12:05
Pat Concannon (USA): Exome sequencing of subjects with unexplained radiation sensitivity identifies novel genes that affect DNA damage responses

12:05-12:30
Tanja Stankovic (UK): Targeting ATM loss in sporadic haematopoietic malignancies

12:30 Lunch

Social Event?

19:00 Dinner

October 14th, Wednesday, 2015

08:00-12:00
ATM-dependent DNA damage response

08:30-08:55
Mike Kastan (USA): ATM: Beyond DNA damage signaling?

08:55-09:20
Axel Behrens (UK): Mechanisms and functions of ATMIN-dependent ATM signaling?

09:20-09:45
Susan Lees-Miller (Canada): New role for DNA-PKcs and ATM in mitosis

09:45-10:10
Kenshi Komatsu (Japan): Roles of NBS1 in radiation-induced chromatin remodeling and a response to UV damage

10:10-10:40
Tea break

10:40-11:05
John Tainer (USA): Mre11-Rad50-Nbs1 functional interactions with ATM and other partners?

11:05-11:30
John Petrini (USA): Nbs1 and the regulation of Mre11 complex-dependent DDR signaling?

11:30-12:00
Selected talks (2 × 15’)

12:00 Lunch

13:00-15:05
ATM-ATR coordinating DNA damage response

13:00-13:25
Lee Zou (USA): Orchestrated Functions of ATM and ATR in DNA Repair?

13:25-13:50
Daochun Kong (China): The intra-S phase checkpoint regulates the replicative helicase CMG complex to stabilize stalled replication forks?

13:50-14:15
Marco Fioani (Italy): Metabolic pathways influencing the DNA damage response: the impact of ATR and ATM

14:15-14:40
Xingzhi Xu (China): Reversible ubiquitination in the replication stress response

14:40-15:05
Kum Kum Khanna (Australia): Single-stranded DNA binding proteins and integrator complex at crossroads of transcription and maintenance of genomic stability

15:05-15:35
Tea break

15:35-17:40
DNA damage response and cancer (II)

15:35-16:00
Qimin Zhan (China): Cell cycle regulator Nlp in the control of mitotic progression and genomic stability

16:00-16:25
Junjie Chen (USA): Protein-protein interaction network in DNA damage response and tumorigenesis

16:25-16:50
Tej Pandita (USA): Role of Chromatin structure in DNA DSB repair pathway choice?

16:50-17:20
Selected talks (2 × 15’)

17:20-17:45?
Andre Nussenzweig (USA): Tumor promoting role of the DNA damage response

17:45-18:10
Steve West (UK): Regulatory control of DNA repair by homologous recombination

18:10-18:30?
Poster awards and closing remarks

18:30
Farewell dinner

學(xué)生或博士后每人1200元；教師或工作人員每人1800元。包含會議資料和10月12-14日的午餐和晚餐。